Clinical gist
نویسندگان
چکیده
منابع مشابه
Clinical and therapeutic considerations of GIST
Gastrointestinal stromal tumors (GIST) are rare tumors of the digestive tract, with an incidence of about 1.5 per 100,000/year. Clinical features may vary depending on location, size and aggressiveness. The diagnosis is confirmed by immunohistochemistry tests that identify CD 117 or DOG1 (typical receptors/markers for most GISTs) at the level of biopsy specimen. The treatment of localized GIST ...
متن کاملPrognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumours (GIST): Polish Clinical GIST Registry experience.
BACKGROUND Majority of gastrointestinal stromal tumours (GISTs) are characterised by KIT-immunopositivity and the presence of KIT/platelet-derived growth factor receptor alpha (PDGFRA) activating mutations. PATIENTS AND METHODS Spectrum and frequency of KIT and PDGFRA mutations were investigated in 427 GISTs. Univariate and multivariate analysis of relapse-free survival (RFS) was conducted in...
متن کاملSmall Bowel GIST: Clinical Presentation as Intussusception and Obscure Bleeding
http://dx.doi.org/10.1016/j.jpge.2015.12.007 2341-4545/© 2016 Sociedade Portuguesa de Gastrenterologia. Published CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4 umors and only 0.04% of small intestinal malignant neolasms. GISTs may occur anywhere along gastrointestinal ract, but most commonly arise in the stomach (40--60%) nd jejunum/ileum (25--30%).1,2 The clinical present...
متن کاملSEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly dee...
متن کاملNon-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions
We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 2016
ISSN: 0032-5473,1469-0756
DOI: 10.1136/postgradmedj-2015-133938