Clinical gist

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Clinical and therapeutic considerations of GIST

Gastrointestinal stromal tumors (GIST) are rare tumors of the digestive tract, with an incidence of about 1.5 per 100,000/year. Clinical features may vary depending on location, size and aggressiveness. The diagnosis is confirmed by immunohistochemistry tests that identify CD 117 or DOG1 (typical receptors/markers for most GISTs) at the level of biopsy specimen. The treatment of localized GIST ...

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Prognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumours (GIST): Polish Clinical GIST Registry experience.

BACKGROUND Majority of gastrointestinal stromal tumours (GISTs) are characterised by KIT-immunopositivity and the presence of KIT/platelet-derived growth factor receptor alpha (PDGFRA) activating mutations. PATIENTS AND METHODS Spectrum and frequency of KIT and PDGFRA mutations were investigated in 427 GISTs. Univariate and multivariate analysis of relapse-free survival (RFS) was conducted in...

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Small Bowel GIST: Clinical Presentation as Intussusception and Obscure Bleeding

http://dx.doi.org/10.1016/j.jpge.2015.12.007 2341-4545/© 2016 Sociedade Portuguesa de Gastrenterologia. Published CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4 umors and only 0.04% of small intestinal malignant neolasms. GISTs may occur anywhere along gastrointestinal ract, but most commonly arise in the stomach (40--60%) nd jejunum/ileum (25--30%).1,2 The clinical present...

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SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016)

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly dee...

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Non-Hodgkin lymphoma and GIST: molecular pathways and clinical expressions

We report the case of a 64-year-old woman with a gastrointestinal stromal tumor and a diffuse large cell lymphoma. For this case, we conducted a literature review in an attempt to correlate these two neoplasms on a molecular basis. Diffuse large cell lymphoma is a subtype of non-Hodgkin lymphomas. The etiologic factor of these lymphomas is considered to be the mutations or allelic losses of the...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 2016

ISSN: 0032-5473,1469-0756

DOI: 10.1136/postgradmedj-2015-133938